Preparation of orally disintegrating tablets from active ingredients of citrus peel by direct powder compression for the maintenance of brain function

Citrus kawachiensis peel (PCK), a new functional food material, may prolong the healthy life expectancy of aging populations. Tableting PCK could facilitate its worldwide distribution and consumption. A dosage form that is easy to swallow should be prepared for ease use by elderly. We investigated fabrication orally disintegrating (OD) tablets with required commercial strength disintegration time. formulated OD comprising powder, crospovidone, vinylpyrrolidone vinyl acetate copolymer, light anhydrous silicic acid, D-mannitol, magnesium stearate. The were using rotary tableting press. was optimized setting target hardness 30−50 N time ≤ 2 min. When performed at compression pressure 7.5 kN, 40 1.5 tablet containing high proportion possessed properties preferred products.